Abstract
Oncotype DX® (ODX) is a valid test of breast cancer (BC) recurrence risk and chemotherapy
benefit. The purpose of this study was to examine prevalence of and factors associated with receipt
of ODX testing among eligible Latinas/Hispanics diagnosed with BC. Sociodemographic and tumor
data of BC cases diagnosed between 2008 and 2017 among Latina/Hispanic women (n = 5777) were
from the New Jersey State Cancer Registry (NJSCR). Eligibility for ODX testing were based on
National Comprehensive Cancer Network guidelines. Multivariable logistic regression models of
ODX receipt among eligible women were used to estimate adjusted odds ratios (AOR) and 95% confidence intervals (CI) by demographic and clinicopathologic factors. One-third of Latinas/Hispanics
diagnosed with BC were eligible for ODX testing. Among the eligible, 60.9% received ODX testing.
Older age (AOR 0.08, 95% CI: 0.04, 0.14), low area-level SES (AOR 0.58, 95% CI: 0.42, 0.52), and being
uninsured (AOR 0.58, 95% CI: 0.39, 0.86) were associated with lower odds of ODX testing. While
there was relatively high ODX testing among eligible Latina/Hispanic women with BC in New Jersey,
our findings suggest that age, insurance status, and area-level SES contribute to unequal access to
genetic testing in this group, which might impact BC outcomes.